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Nov 4th, 2005 - 13:53:49 

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Skin Care

Use of Restylane for the Treatment of Facial Wrinkles
By Dr. Dan Ladd
Austin Skin Institute
Apr 29, 2004, 10:36

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What is Restylane?

Restylane is a crystal-clear, non-animal, biodegradable gel based on a natural substance, called hyaluronic acid. The gel is injected into the skin in tiny amounts with a very fine needle. The result is instantaneous and produces a long-lasting, natural enhancement, gentle and safe to your skin.  

Is Restylane safe?

Yes Restylane is a safe product, made of hyaluronic acid, which is naturally present in the body. Restylane was the first FDA-approved, non-animal, stabilized, injectable hyaluronic acid for aesthetic use. As it is free from 

animal substances, the risk of transmitting diseases from other species is completely eliminated. To date, more than a million treatments have successfully been carried out with Restylane in more than 60 countries worldwide.  


Is Resytlane effective?

In a clinical study in the USA in which Restylane was compared with a collagen-based product, the effect with Restylane was better in six times as many patients as the product with which it was being compared. The study began in 2001 and comprised a total of 138 patients treated at six leading clinics in the USA. Six months after the initial treatment, a follow-up was conducted. The wrinkles that were treated were the so-called nasolabial folds, which run from the bridge of the nose to the corner of the mouth.

Before                                         After

Is Restylane a naturally occurring product?

Yes Restylane is produced by the naturally occurring Streptococcus bacteria.  No bacteria are contained in the final Restylane product.

Why do I need the hyaluronic acid in Restylane to help my face look younger?

Young skin is smooth and elastic and contains a large amount of hyaluronic acid that helps the skin retain moisture and look healthy. As we grow older, the ability of the skin to produce hyaluronic acid decreases and the amount of hyaluronic acid begins to fall.  The resultant loss of skin fullness also means that the skin becomes looser. This leads to wrinkling, folds and the older appearance of the skin.  As you can see from the before and after photos on this website, replacing hyaluronic acid plumps up the skin just below the wrinkles and restores the volume, diminishing the appearance of the wrinkles. 

Before                                        After

How quickly will I see the results of Restylane?

Achieving the look you desire is as easy as it is quick. The result is instantaneous. No previous skin test is needed, which means that you can have the treatment immediately. The session often takes less than thirty minutes. The time differs somewhat depending on the correction you want to have performed.

Before                                             After

How long will my Restylane last? 

As your face is constantly changing, beauty is best maintained by evaluating the need for further treatment from time to time. With Restylane, you are always in charge of your looks. With Restylane, you always have the option of continuing or changing the combination of treatments. The treatment can be repeated as often as you like.  Most patients seek retreatment in 6-9 months.

Before                                              After

Can a combination of Restylane and Botox be more effective and less painful than either treatment alone?

A Canadian study suggests that combination treatment with Restylane and Botox is more effective than either product on its own for correcting glabellar lines (lines between the eyebrows). The combination of Restylane and Botox proved significantly more effective than Restylane alone over a 28-week follow-up period. The study also revealed that injection-related pain was rated as lower when Restylane was injected after Botox, suggesting that Botox has some analgesic effect. (Carruthers, A. New evidence of hyaluronic acid (NASHA) as a dermal filler. 11th congress of the EADV, Prague, Czech Republic; 4 Oct 2002)

This article is provided by Austin Skin Institute.  Used with permission.


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The medical information provided in this site is for educational purposes only.  Any topic discussed in this article is not intended as medical advice. It is not intended nor implied to be a substitute for professional medical advice and shall not create a physician - patient relationship. Consult a dermatologist, if you have a specific question or concern about a skin lesion or disease.
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